Hanchuan Peng of Janelia Farm spoke on bioimaging at ISB a couple weeks back. He's doing some very cool work mining microscopy images doing registration - aligning individual cells across images. They've created a 3D atlas of C. elegans which tracks every cell. The still pictures don't don't do it justice. Check out the movies.
By localizing and registering neural fibers in 2,954 fly brains, Peng's group constructing this wiring diagram of the fly's 100,000 neurons.
- A 3d digital atlas of C. elegans and its application to single-cell analyses, Nature Methods 2009
- BrainAligner: 3d registration atlases of Drosophila brains, Nature Methods 2011