Hanchuan Peng of Janelia Farm spoke on bioimaging at ISB a couple weeks back. He's doing some very cool work mining microscopy images doing registration - aligning individual cells across images. They've created a 3D atlas of C. elegans which tracks every cell. The still pictures don't don't do it justice. Check out the movies.
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgQFRqQR7J8ANR5vx1jGJccKMflg640oZ6QcMRL9brpuBV-YxiZ4LRSKilli7er_xZLn-crnX_tiHEutoUDgRLLacyAkalxnXcOW8YLXR0CP6jAo2pxTvf9r7O6ZBzoS3WfkQOECBgsRe6i/s400/c_elegans.png)
By localizing and registering neural fibers in 2,954 fly brains, Peng's group constructing this wiring diagram of the fly's 100,000 neurons.
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhQ1bYQlL0OjiCC-vdbtZrRB7n-DQSOgHutuANrcvwOr__1lRD3s_j6F8j3o6EWzErNECZmZyXQlarpQiNVRvi4EAEWFjrqqEbXVgwx2V1kVvgRlS3DGMMyzTH8GQ-wMKFq9WrFhgxQZQvd/s400/fly_brain.png)
More
- A 3d digital atlas of C. elegans and its application to single-cell analyses, Nature Methods 2009
- BrainAligner: 3d registration atlases of Drosophila brains, Nature Methods 2011
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